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Use of Perfusate of Balanced Electrolytes and Low Molecular Weight Dextran

B. B. ROE, MD; E. E. SWENSON, RN; S. A. HEPPS, MD; D. L. BRUNS, MD

AMA Arch Surg. 1964;88(1):128-134.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Extracorporeal oxygenation has distinct hazards and limitations which are inherent in the basic process of gas exchange. Clinical and laboratory studies have demonstrated that all currently available methods of oxygenation (bubbling, filming, and membrane) result in varying degrees of pathologic change in the lungs, kidneys, and brain.^2,3,6,10 In the early stages of extracorporeal circulation, undoubtably some damage to the blood occurred from suction, turbulence, and pumping, and foreign material may have been introduced in the form of pyrogens, gas bubbles, or antifoaming agents. In general, however, these sources of damage have been removed or reduced to a minimum, and they now account for a relatively small proportion of the tissue changes with which we are concerned.

Alteration in the blood elements appears to occur at the gas-fluid interface. The resulting phenomena include atelectasis, fluid transudation, and intravascular agglutination of erythrocytes.¹¹ A loss of surface-active agent has also been . . . [Full Text PDF of this Article]

Author Affiliations
SAN FRANCISCO

From the Department of Surgery, University of California Medical Center.

Footnotes
Read before the 11th Scientific Meeting of the International Cardiovascular Society, North American Chapter, Atlantic City, NJ, June 15, 1963.

This work was done during tenure of an Advanced Research Fellowship of the American Heart Association (Dr. Hepps).

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