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Antithrombogenic Effect

E. W. WINFREY, III, MD; JOHN H. FOSTER, MD

AMA Arch Surg. 1964;88(1):78-82.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In recent years extensive studies of the physiological properties of low molecular weight dextran (average molecular weight 40,000) have been conducted on both an experimental and a clinical level. These studies have centered predominantly around the use of dextran as a plasma substitute and its characteristic property of increasing the rate of blood flow through the smaller arteries, capillaries, and venules.

The purpose of this study was to determine the effect of low molecular weight dextran in preventing early thrombosis of small arteries subjected to operative trauma.

Two acute thrombus-producing procedures were carried out utilizing the carotid and femoral arteries of mongrel dogs (Fig 1). The vessels had an average diameter of 3.5 mm, and the animals ranged in weight from 10 to 12 kg. Anesthesia was achieved and maintained with intravenous veterinary pentobarbital sodium (Nembutal).

The first procedure consisted of a small transverse arteriotomy with removal of 2 cm . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN.

Presently, Instructor in Surgery, The George Washington University School of Medicine (Dr. Winfrey).; From the S. R. Light Laboratory for Surgical Research and the Department of Surgery, Vanderbilt University Medical Center.

Footnotes
Read before the 11th Scientific Meeting of the International Cardiovascular Society, North American Chapter, Atlantic City, NJ, June 15, 1963.

Studies supported in part by contract DA-49-007-MD-697, Research and Development Division, Office of the Surgeon General, Department of US Army (Dr. Foster).

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