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Its Effect on Serum and Urine Sodium Concentration

FREDERICK W. CHENEY, JR., MD; PETER W. RAND, MD; JOHN R. LINCOLN, MD

AMA Arch Surg. 1964;88(2):197-205.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In the past several years there has been renewed interest in the osmotic diuretic mannitol. In abdominal aortic aneurysmectomy mannitol has been widely used to maintain renal plasma flow and urinary output during cross-clamping of the abdominal aorta.¹ Increased urinary output during and after aortic surgery has been described in the literature^2,3 and confirmed by our own experience with the drug.

Some discrepancies exist in published reports as to the amount of sodium lost in the urine during mannitol diuresis and the significance of this loss. In nonanesthetized, resting humans separate studies have shown that with mannitol diuresis there is increased sodium excretion with a significant decrease in serum sodium.^4,5 Boba, Gainor, and Powers⁶ have shown that anesthetized traumatized dogs infused with 10% mannitol undergo considerable urine sodium loss with marked decreases in serum sodium. Whelan,³ on the other hand, has reported that urine . . . [Full Text PDF of this Article]

Author Affiliations
PORTLAND, ME

Resident, Department of Anesthesiology, Maine Medical Center (Dr. Cheney); Research Associate, Maine Medical Center (Dr. Rand); Director, Department of Anesthesiology, Maine Medical Center (Dr. Lincoln).

Footnotes
Received for publication Aug 22, 1963.

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