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WILLIAM H. CHOATE, MS; JORGE O. JUST-VIERA, MD; GEORGE H. YEAGER, MD

AMA Arch Surg. 1964;88(2):249-254.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The development of postoperative adhesions following abdominal surgery is not completely understood. Factors governing individual response leading to extensive adhesions in some patients and their absence in others remain unexplained. Most reports directly relate the formation of adhesions to the amount of trauma inflicted during operative handling and manipulation of tissues.¹ Many experimental methods have been studied in an attempt to decrease postoperative adhesions because of their importance as a cause of intestinal obstruction. Recently, Knightly et al² and Spagna and Peskin³ reported on the use of fibrinolysin to prevent adhesions in rats. The dose of fibrinolysin necessary to eliminate all adhesions was lethal in some animals. Investigation of less noxious substances seems justified.

Dextran has been used successfully to prevent thrombosis of small arteries and large veins following trauma to the intima.^4,5 The mechanism by which dextran prevents thrombosis remains obscure. The total plasma volume . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

Pangborn Fellow in Peripheral Vascular Disease (Dr. Just-Viera); from the Department of Surgery, University of Maryland School of Medicine (Dr. Yeager).

Footnotes
Received for publication Sept 23, 1963.

This study was supported by the Pangborn Fund and by USPHS grant no. H-7171-2.

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