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HENRY SWAN, MD; ALEXANDER ALEXICH, MD; JAMES LISTER, FRCS; THOMAS MARCHIORO, MD; BRUCE D. PATTON, FRCS

AMA Arch Surg. 1964;88(3):448-451.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A standard experimental preparation has been developed for the study of acute experimental hemorrhage, based on the principle of bleeding a certain percentage of the predetermined blood volume of the animal. Previous work from this laboratory has shown that by bleeding a definite percentage of the measured blood volume of the experimental animal, the mortality rate could be predicted with an accuracy ranging within ±5%.¹

Further work along these lines, however, revealed a conspicuous, constant, and significant difference in mortality rates between groups of dogs subjected to acute hemorrhage under strictly the same and standard experimental conditions, but at different seasons of the year. The possibility of a seasonal variation in the tolerance of dogs to acute hemorrhage was suspected, and this suspicion stimulated the development of this study.

Material and Method

Throughout 1960-1961, a total of 112 adult mongrel dogs were subjected to acute experimental hemorrhage at different . . . [Full Text PDF of this Article]

Author Affiliations
DENVER

From the Halsted Laboratory for Experimental Surgery, University of Colorado School of Medicine.

Footnotes
Submitted for publication Dec 4, 1963.

This work was supported in part by a contract with the Surgeon General of the United States Army DA-49-007-MD-572.

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