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Development of Metastases of Walker 256 Carcinosarcoma

DOMENICO AGOSTINO, VMD; EUGENE E. CLIFFTON, MD

AMA Arch Surg. 1964;88(5):735-739.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has been observed that malignant tumors occasionally seem to spread more rapidly after operation. This has never been proven statistically, nor has an adequate explanation been found. In experimental animals surgical stress in some instances may influence the growth of cancer. This factor may be due either to an increased virulence of the tumor or to a decreased resistance of the host to the tumor. Stress in animals has been produced by many means such as amputation of the limb bearing the tumor,¹⁵ or of another limb,¹³ by laparotomy,³ by liver massage,⁷ or by local trauma¹⁴ with a consequent increase in metastases. In other instances the stress has been produced by inoculation of chemicals such as formaldehyde solution (formalin),²³ turpentine,¹ or carbon tetrachloride.⁴ The results mentioned could be due to adrenal stimulation and increased adrenocorticosteroids. Cortisone increases the metastatic growth in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Research Associate, Sloan-Kettering Institute for Cancer Research (Dr. Agostino); Associate Professor of Clinical Surgery, Cornell University Medical College; Associate Member, Sloan-Kettering Institute for Cancer Research (Dr. Cliffton).; From the Memorial Sloan-Kettering Cancer Center and Cornell University Medical College.

Footnotes
Submitted for publication Aug 19, 1963.

This work was supported by grant No. T258 of the American Cancer Society, HE-02867-06 of the National Institutes of Health, No. C-3817 of the National Cancer Institute, and institutional funds.

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