This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

EINO NELSON, PhD; GERHARD LEVY, PharmD

AMA Arch Surg. 1964;88(6):921-922.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A recent report in this journal of a case of renal tubular necrosis and death after oral cholecystography¹ and similar reports recently published elsewhere^2,3 have prompted us to submit the present communication which deals with (a) a possible mechanism for renal damage caused by cholecystographic agents, (b) measures which may prevent or reduce the likelihood of renal injury, and (c) other aspects of the pharmacodynamics of cholecystographic agents which deserve consideration in connection with the observed toxic effects of these agents.

Cholecystographic agents are weak acids with low solubility in aqueous media. Their solubility increases at higher pH to an extent depending upon their acid dissociation constant (K_a) and the pH of the aqueous medium. In a previous report,⁴ one of us (E. N.) has shown that, on the basis of their physicochemical properties and the presently available knowledge of their metabolic fate, most cholecystographic agents . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO

Chairman of the Department of Pharmaceutics and Professor of Pharmaceutics and Medicinal Chemistry (Dr. Nelson); Associate Professor of Pharmacy and Biopharmaceutics (Dr. Levy).; From the Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo.

Footnotes
Submitted for publication Jan 2, 1964.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?