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Effect of Gastroenterostomy and Pyloroplasty on Chronic Gastric Ulcers Produced by Vagotomy in Rabbits

CARLOS A. LINARES, MD; CARLOS de la ROSA, MD; EDWARD R. WOODWARD, MD; LESTER R. DRAGSTEDT, MD

AMA Arch Surg. 1964;88(6):932-938.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1901 Van Yzeren¹ discovered that subdiaphragmatic division of the vagus nerves to the stomach in rabbits frequently caused the development of chronic gastric ulcers. He believed these lesions were due to spasm of the gastric musculature and could sometimes be prevented by section of the muscles in the pyloro-antrum area or by gastroenterostomy. Auer² confirmed these observations and pointed out that the incidence of these experimental gastric ulcers increased in those rabbits that survived the vagotomy for several months. Beazell and Ivy³ likewise observed gastric ulcers in rabbits following vagotomy, and implicated stasis of coarse food in the stomach as a factor, but not the only one, in their development.

These reports of gastric ulcers appearing in animals after vagotomy were very disturbing to one of us (L. R. D.) when the introduction of gastric vagotomy was being considered for the treatment of duodenal ulcers. It . . . [Full Text PDF of this Article]

Author Affiliations
GAINESVILLE, FLA

Research Assistant supported by a grant from the Consejo Nacional de Investigaciones Cientificas y Technicas, Republica Argentina (Dr. Linares); Research Assistant (Dr. de la Rosa); Professor and Chairman, Department of Surgery (Dr. Wood-ward); Research Professor (Dr. Dragstedt).; From the Department of Surgery of the University of Florida, Gainesville, Fla.

Footnotes
Submitted for publication Jan 20, 1964.

This work has been aided by grants from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.

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