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BERNARD W. THOMPSON, MD; RAYMOND J. LIPIN, MD; ROBERT L. CLARK, MD

AMA Arch Surg. 1964;88(6):966-968.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The mortality rate in acute hemorrhagic pancreatitis remains high despite all therapeutic measures and much experimental work. Theoretically it would seem that any measure tending to suppress the activity of the pancreas would aid in the management of this disease. Reid and Kossa⁸ have shown that thiourea and its analogues owe their antithyroid action, in part at least, to their antioxidant property in all organs and tissues. As a consequence, there is a decrease in the amount of energy released, less product formed, and the organ placed at rest. Propylthiouracil appears to be the most active in lowering the metabolic activity in the various organs, and particularly in the pancreas.

In a preliminary report, we¹¹ have shown that propylthiouracil given both preoperatively and also after the onset of pancreatitis, is effective in lowering mortality rate by slowing pancreatic activity. In an analogous study, using hypothermia to suppress pancreatic . . . [Full Text PDF of this Article]

Author Affiliations
LITTLE ROCK, ARK

From the Department of Surgery, Veterans Administration Hospital, Little Rock Division.

Footnotes
Submitted for publication Jan 7, 1964.

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