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HECTOR M. MARIN, MD

AMA Arch Surg. 1964;88(6):988-998.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

As the technique of extracorporeal perfusion becomes perfected, the demands made upon it increase. Progressively longer perfusions for more complicated operations upon the heart valves magnify the complications of the perfusion itself. One of the most significant of these complications is postperfusion bleeding.

Von Kaulla and Swan^25-27 attributed hemorrhagic complications to the association of fibrinolysis and a circulating anticoagulant. Perkins et al^15,16 emphasized the role of thrombocytopenia, improper heparin neutralization, and the denaturation of some of the coagulation proteins. Rothney^20,21 observed hypofibrinogenemia in one patient perfused for 2 hours. The lack of unanimity among the various authors is more apparent than real, since several deficiencies play a role in causing postoperative bleeding. In addition, the coagulation factors are so closely interrelated that a change in one factor is seldom a self-limited phenomenon, but often starts a reaction which involves many or all the other factors.

The . . . [Full Text PDF of this Article]

Author Affiliations
WEST ROXBURY, MASS

From the Veterans Administration Hospital.

Footnotes
Submitted for publication Jan 11, 1964.

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