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Hemorrhagic Necrosis of the IntestineA Clinical Syndrome: Presence Without Organic Vascular Occlusion
WILLIAM R. DRUCKER, MD;
JOHN H. DAVIS, MD;
WILLIAM D. HOLDEN, MD;
JAMES R. REAGAN, MD
AMA Arch Surg. 1964;89(1):42-53.
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Introduction
Extensive hemorrhagic necrosis of the bowel mucosa without associated mesenteric vascular occlusion is a characteristic feature of dogs dying of shock.1-3 While this is a recognized feature of endotoxin,4-7 adrenalin,8-10 or hemorrhagic11,12 shock in dogs, it is notably absent in humans dying of hypovolemic shock. Consequently it was thought interesting to observe seven patients, within the space of two years, who were found either at the time of laparotomy or at autopsy to have hemorrhagic necrosis of the bowel without demonstrable occlusion in the mesenteric vessels.
No completely satisfactory explanation exists regarding the characteristic hemorrhagic necrosis of mucosa associated with experimental shock. However, the remarkable similarity between the intestinal lesions of man and the dog suggested that they may have a common pathogenesis.
Case Material
Briefly the cases that constitute this study are summarized in Tables 1 and 2.
An 84-year-old white male was admitted
. . . [Full Text PDF of this Article]
Author Affiliations
CLEVELAND
From the departments of surgery and pathology, Western Reserve University, School of Medicine and University Hospitals of Cleveland.
Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.
Supported in part by United States Public Health Service grants No. A1253 and AM-05288.
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