This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (19)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Animal Experimentation and Preliminary Results in Human Application

IRVING M. ARIEL, MD

AMA Arch Surg. 1964;89(2):244-249.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

The most frequent reason for failure to cure most cancers is the vascular spread of the tumor. The two organs to which metastases most frequently occur are the liver and the lungs. Attempts to prevent the "take" of the tumor emboli in these organs or to discourage their growth once they have lodged in these organs have been made by Dr. Warren H. Cole and his associates, utilizing chemotherapeutic agents. They have demonstrated that certain chemotherapeutic agents, administered at the same time that tumor inocula are introduced into experimental animals, exert an influence in discouraging the "take" or growth of such neoplasms. At the clinical level such efforts have been discouraging. A nationwide study in which chemotherapeutic adjuvant theray was administered at the time curative resections were performed for cancers of the lung, stomach, rectum, and breast revealed no beneficial effects for the first three, but a possible beneficial . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Soft Somatic Tumor Service, Hospital for Joint Disease, and the Pack Medical Foundation.

Footnotes
Submitted for publication Jan 27, 1964.

Supported in part by grants-in-aid from the Harold Brady Cancer Research Fund.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?