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Mechlorethamine HydrochlorideEffect on Healing of Bronchial Stump
CHARLES G. LONGENECKER, MD;
EDWARD T. KREMENTZ, MD
AMA Arch Surg. 1964;89(2):266-269.
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The use of chemotherapeutic agents as an adjunct to operative management of malignant disease is receiving considerable attention in current cancer research. Since the effects of these highly toxic drugs are not entirely limited to neoplastic tissue, however, knowledge of their effects on normal healing of wounds would be valuable. Krementz and associates9 called attention to the decrease in tensile strength of healing wounds following the use of alkylating agents in 1957 and documented this in an experimental study concerning gastrotomy wounds in guinea pigs treated with triethylenemelamine. In many instances, complications after surgical treatment of cancer of the lung may possibly be due to the adjuvant use of mechlorethamine hydrochloride (nitrogen mustard) with resultant deleterious effects on wound healing. The present study was undertaken in order to determine if local and systemic use of mechlorethamine hydrochloride, as followed in the national cooperative adjuvant chemotherapy study for carcinoma of
. . . [Full Text PDF of this Article]
Author Affiliations
NEW ORLEANS
Trainee, National Cancer Institute Training grant, CRYT-5018, Department of Surgery, Section of Plastic Surgery, Tulane University School of Medicine (Dr. Longenecker); National Cancer Institute Research Career Development Awardee, CA-K6-1087-02, Department of Surgery, Tulane University School of Medicine (Dr. Krementz).
Footnotes
Submitted for publication Jan 27, 1964.
Aided by a grant from the American Cancer Society, Louisiana Division, Inc., and by U.S.P.H.S. Grant No. 22865 from the National Cancer Institute.
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