This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (92)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Relationship in Experimental and Human Pancreatitis

W. KATZ, MD; M. SILVERSTEIN, MD; E. E. KOBOLD, MD; A. P. THAL, MD

AMA Arch Surg. 1964;89(2):322-331.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

As early as 1916 Peterson¹ suggested that the fulminating nature of acute hemorrhagic pancreatitis was directly related to the digestion of plasma proteins by proteolytic enzymes. In 1950, Werle² published his classic work on the hypotensive proteolytic material from the pancreas, kallikrein, and more recently, kallikrein was partially purified by Westerfield³ and Webster and Clark⁴ and shown to produce hypotension. Rocha e Silva,^5,6 after demonstrating the ability of trypsin to release bound stores of histamine, discovered that trypsin also released from plasma -2 globulins the hypotensive polypeptide bradykinin in much the same fashion as renin liberates the hypertensive polypeptide angiotensin. The object of the present investigation is to measure the liberation of proteolytic enzymes in pancreatitis and to relate this to the release of substances affecting vascular smooth muscle and capillary permeability.

Materials and Methods

1. Experimental Pancreatitis.

—Healthy, adult mongrel dogs, ranging in weight . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the Robert S. Marx Surgical Laboratories, Wayne State University College of Medicine, and Department of Surgery, Detroit Receiving Hospital.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

Supported by National Institutes of Health grant AM 06385-02, Michigan Heart Association and Receiving Hospital Research Corporation.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?