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Tolerance in Normothermic and Hypothermic Animals at 1.0 and 3.4 Atmospheres Absolute

EDWARD S. TANK, MD; GIANFRANCO FRITTELLI, MD; GORDON F. VAWTER, MD; WILLIAM F. BERNHARD, MD

AMA Arch Surg. 1964;89(2):340-343.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although successful subtotal hepatic resections for neoplastic and traumatic lesions have been carried out, the scope of this procedure is limited by the extreme vascularity and friability of hepatic tissue.^1-4 In the past, control of hemorrhage from the liver has been effected by short periods of occlusion of the hepatic afferent blood supply at normal body temperature. More recently, the use of moderate hypothermia has considerably extended the safe period of inflow occlusion, although sustained periods of ischemia still introduce the risk of liver necrosis.

Previous investigators have determined the tolerance of normothermic and hypothermic dogs to total hepatic afferent occlusion under normobaric conditions.^5,6 At normal body temperature (37 C), ischemic periods of 20 minutes are well tolerated while longer intervals of interruption of hepatic blood flow are associated with a mortality rate which approaches 100% at 60 minutes. Surface cooling to a mean body temperature of 25-31 . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH

Research Fellow in Surgery, Children's Hospital Medical Center and Research Fellow in Surgery, Harvard Medical School (Drs. Tank and Frittelli); Pathologist, Children's Hospital Medical Center and Assistant Clinical Professor of Pathology, Harvard Medical School (Dr. Vawter); Associate Surgeon and Director of Surgical Research Laboratory, Children's Hospital Medical Center, Clinical Associate in Surgery, Harvard Medical School (Dr. Bernhard).; From the Surgical Research Laboratory, Children's Hospital Medical Center, Boston.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

These studies were supported by research grants from the National Heart Institute, National Institutes of Health, United States Public Health Service, American Heart Association, and the Greater Boston Chapter of the Massachusetts Heart Association.

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