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Studies of Changes in This Course Produced by a Vasoconstrictor and an Adrenergic Blocking Agent During Readjustment to Hemorrhagic Shock

LAWRENCE POLLOCK, MD; KJARTAN B. KJARTANSSON, MD; N. ANDERS DELIN, MD; WORTHINGTON G. SCHENK, JR., MD

AMA Arch Surg. 1964;89(2):344-354.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Although there has been extensive investigation of varied shock states,* disagreement continues on whether, after adequate volume replacement, therapy should include vasoconstrictors, ganglionic blocking agents, pH stabilizers, or other drugs. This study was designed to investigate the course of splanchnic and somatic blood flow distribution during spontaneous, untreated recovery from a single severe hemorrhagic episode. Then, utilizing this spontaneous recovery course as a control pattern, the effects of a vasoconstrictor or an adrenergic blocking agent could be evaluated.

Methods and Materials

Thirty healthy mongrel dogs weighing between 12.7 and 25.5 kg were anesthetized with intravenous sodium pentobarbital, 26 mg/kg, intubated and placed on a Jefferson ventilator. The left external jugular vein was cannulated with a polyethylene catheter and isotonic saline infused at a rate of 1 cc/min. The left common carotid artery was likewise cannulated and attached to a Sanborn inductance transducer for continuous monitoring of blood pressure. Another polyethylene . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO

Research Fellow of the United Health Foundation of Western New York (Dr. Delin).; From the Department of Surgery, State University of New York at Buffalo and the Edward J. Meyer Memorial Hospital.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

Supported in part by United States Public Health Service grant No. HE 03181 of the National Heart Institute.

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