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Part 1. Control Group and Shock Patients Resuscitated Prior to Low Molecular Weight Dextran Therapy

ROBERT J. BAKER, MD; WILLIAM C. SHOEMAKER, MD; FUJIO SUZUKI, MD; ROBERT J. FREEARK, MD; E. LEE STROHL, MD

AMA Arch Surg. 1964;89(2):373-379.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A wealth of information has accumulated over the past 30 years on the problems relating to shock, a great deal of which was derived from animal experimentation. Despite the tremendous value of such studies, it has long been recognized that the controlled shock of the laboratory is frequently a far cry from the clinical situation engendered by deep shock.

Laboratory and clinical observations have sought to illuminate shock problems in two spheres, namely, pathophysiologic mechanisms, and, subsequently, appropriate, effective treatment. Unfortunately, mechanisms observed in the laboratory and at the bedside did not seem consistently to be identical, and, more often, treatment did not seem to have the same, or even similar, results.

One obviously dissimilar feature between the experimental model and its human counterpart is the number of factors involved. The Wiggers preparation, encompassing controlled, graded hemorrhage and volumetric replacement in the dog, is not a clinical phenomenon. The . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Surgical Research, Division of Surgery, and the Hektoen Institute of the Cook County Hospital, and the departments of surgery of the University of Illinois College of Medicine and the Chicago Medical School.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

Supported in part by United States Public Health grant No. HE 08512, United States Public Health Career Research Award No. 1-K6-HE-6305, and by the Charles H. and Rachel M. Schwab Memorial Foundation.

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