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Clinical Significance

NORMAN C. DELARUE, BA, MD, MS (TOR.), FRCS (C), FACS, FCCP; NEIL WATTERS, MD, FRCS (C); W. E. ANDERSON, MD; DONALD THOMPSON, MD; T. C. BROWN, MD, FACP; R. E. FALK, MD; G. S. LANSKY, MD; R. H. N. FIELDEN, MD; G. LAU, MD; DONALD STEELE, MD

AMA Arch Surg. 1964;89(2):392-398.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Many students of the problem have been puzzled and fascinated by the possible pathological and clinical significance of certain cells found to be circulating in the peripheral blood of patients known to harbour malignant diseases of infinite variety. Theoretical and practical aspects of this matter have been discussed previously.¹

Almost every facet of these studies remains to date open to doubt and conjecture. These doubts revolve not only around the frequency^2-7 with which such cells can be recovered but are expressed also concerning their pathological identification^2,4,8,9 and consequently their prognostic implications.

The variation in frequency can logically be related to the fortuitous timing of the samplings and their small volume, and can also be explained partially on the more factual bases of differences in the technique of recovery on cytological examination and the nature and extent of the specific diseases under study. Not only is the volume . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO

Department of Surgery (Dr. Delarue), pathologist (Drs. Anderson and Thompson), Ontario Cancer Treatment and Research Foundation Fellow, Department of Surgery (Drs. Falk, Lansky, Fielden, Lau, and Steele), Toronto General Hospital; Department of Surgery (Dr. Watters), pathologist (Dr. Brown), Wellesley Hospital.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

The Ontario Cancer Treatment and Research Foundation provided financial assistance, making possible the assignment of Fellows to this project for collecting the specimens, recording the clinical and pathological data, and maintaining the follow-up reports.

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