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Utilization of Radioactive Microspheres

ROBERT J. BLANCHARD, MD; IVAN GROTENHUIS, MS; JAMES W. LaFAVE, MD; CHARLES W. FRYE, MD; JOHN F. PERRY, JR., MD

AMA Arch Surg. 1964;89(2):406-410.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Experimental and clinical studies evaluating the usefulness of radioactive microspheres in treatment of tumors have been in progress since 1960. Ceramic or plastic in composition, these spheres have been found to have many uses in industry. As carriers of radioactive isotopes they have several features favorable to medical application.¹ Almost any cation can be incorporated as the microspheres act like exchange resins. The bond is then made permanent by firing in a kiln. Very high specific activities can be achieved (up to 10 curies Y⁹⁰/gm). The spheres can be accurately segregated into groups of uniform size varying from 15µ to 500µ. Finally, the spheres themselves are biologically inert and resist leaching even in strong acids and/or alkalis.

In experiments previously reported by LaFave and associates² it was shown that the administration of Y⁹⁰ microspheres into the rabbit mesenteric vein along with VX2 carcinoma cells prevents . . . [Full Text PDF of this Article]

Author Affiliations
ST. PAUL

From the departments of surgery and radiation therapy, Ancker Hospital, and the University of Minnesota Medical School, Minneapolis.

Footnotes
Read before the 21st Annual Meeting of the Central Surgical Association, Rochester, Minn, Feb 27-29, 1964.

Supported by research grant No. AT(11-1)-1305 Atomic Energy Commission, and a grant from the United Fund of St. Paul.

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