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RODRIGO QUINTANA, MD; SOICHI KOHATZU, MD; EDWARD R. WOODWARD, MD; LESTER R. DRAGSTEDT, MD

AMA Arch Surg. 1964;89(4):585-591.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Pure gastric juice, as it is secreted by the fundus of the stomach, is an exceedingly corrosive liquid and has the capacity to digest away the normal mucous membrane of the stomach, duodenum, or small intestines and produce a defect indistinguishable from the chronic progressive peptic ulcers seen in patients.¹ The mucous membrane is exposed to such pure gastric juice, either when gastric secretion is stimulated by agencies other than food or when an excessive secretion occurs, so that the buffering capacity of food, gastric mucus, swallowed saliva, and regurgitated secretions is overcome. Under normal conditions the mucosa is protected by these buffering agencies and also by an autoregulatory mechanism in the gastrointestinal tract itself. This mechanism provides for a stimulation of gastric secretion during food taking and a check of further secretion when sufficient gastric juice has been secreted to digest the food and before the gastric content . . . [Full Text PDF of this Article]

Author Affiliations
GAINESVILLE, FLA

From the Department of Surgery of the University of Florida.

Footnotes
Submitted for publication March 14, 1964.

This work has been aided by grants from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.

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