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The Circulatory Effects of Levarterenol, Hydrocortisone, Phenoxybenzamine Hydrochloride, and Blood Volume Expansion

LOUIS L. SMITH, MD; WALTER MULLER, MD; DAVID B. HINSHAW, MD

AMA Arch Surg. 1964;89(4):630-636.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Shock associated with infection is a serious cardiovascular complication associated with a high mortality. Many facets of this complex circulatory disturbance remain obscure; however, the clinical features are quite characteristic. Bacterial shock is often observed in patients with Gram-negative infections. Cardiovascular collapse usually follows the abrupt onset of hyperpyrexia and chills, suggesting the entrance of bacteria or bacterial products into the blood stream. Despite intensive treatment, the mortality rate in this type of shock is uniformly high.

Current therapy has been directed toward the control of the initiating infection. Supportive measures have included the use of vasopressors, pharmacological doses of corticosteroids,* and plasma volume replacement. Vasodilator drugs have been suggested since they have been successful in lowering mortality in pretreated animals subjected to endotoxic shock.

Despite the widespread use of the therapeutic agents listed above, little specific data is available regarding their effect on circulatory dynamics in the management of . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

Associate Professor of Surgery, Director of the Surgical Research Laboratory (Dr. Smith); Surgical Research Fellow (Dr. Muller); and Professor and Chairman, Department of Surgery (Dr. Hinshaw), Loma Linda University.; From the Department of Surgery and Surgical Research Laboratory, Loma Linda University School of Medicine.

Footnotes
Submitted for publication April 10, 1964.

Supported by United States Public Health Service grant No. HE 4639, National Heart Institute.

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