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An Experimental Study in Dogs Following Hemorrhage and After Infusion of Dextrans, Saline, Plasma, and the Shed Blood

WORTHINGTON G. SCHENK, JR., MD; N. ANDERS DELIN, MD; ERWIN DOMANIG, MD; PAUL HAHNLOSER, MD; RONALD K. HOYT, MD

AMA Arch Surg. 1964;89(5):783-796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Increasing importance of the role of blood viscosity alterations in various "flow problems," such as shock, hypothermia, extracorporeal circulation, thromboembolism, and peripheral vascular surgery is suggested by the growing popularity of this topic in current medical literature.^{1,4,9,10,14,18,21} Experimental and clinical studies have documented changes in cardiac output, myocardial contractility, and peripheral vasomotor tone in shock, whereas only recent attention has been given to changes occurring in the microcirculation, arbitrarily defined as that complex of arterioles, capillaries, and venules with internal diameters of less than 100µ.¹⁸ Interest in the subject of viscosity has been heightened through basic investigations by Swedish investigators of low viscous dextran (LVD) or low molecular weight dextran (LMDX) and its flow and viscosity altering properties.^7,17

This report concerns the effect of viscosity alterations on blood flow in an animal under conditions of experimental shock, documenting these changes with actual measurements of viscosity and . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO, NY

Research Fellow of the United Health Foundation of Western New York (Drs. Delin and Hahnloser).; From the Department of Surgery, State University of New York at Buffalo and the Edward J. Meyer Memorial Hospital.

Footnotes
Read before the 12th Scientific Meeting of the International Cardiovascular Society, North American Chapter, San Francisco, June 20, 1964.

Supported in part by a grant-in-aid from the National Heart Institute of the United States Public Health Service (HE-03181).

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