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Alterations in Morphology of Heart

THEODORE COOPER, MD; EDWIN F. HIRSCH, MD; VALLEE L. WILLMAN, MD; C. ROLLINS HANLON, MD

AMA Arch Surg. 1964;89(5):915-920.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Histologic examination of the homografted heart at the time of "rejection" shows round cell infiltration, interstitial hemorrhage, edema, and necrosis.^1-3 With the obvious histocompatibility of cardiac autografts one would not anticipate these specific alterations in histologic appearance. However, with electron microscopy we have demonstrated certain changes in intercellular structure after excision and reimplantation of the heart.⁴ Neural elements are principally involved. Therefore, we have examined the morphology of normal canine hearts and hearts subjected to sham operation, autotransplantation, and homotransplantation. Using silver impregnation and trichrome counter stain we have attempted to evaluate the effect of these operations on neural and collagenous elements in the heart.

Methods

Studies were carried out on four groups of mongrel dogs: (1) three normal controls; (2) two animals subjected to sham operation, including thoracotomy, extracorporeal circulation, hypothermia, and cardiac arrest; (3) five orthotopic cardiac autotransplants; (4) two dogs subjected to cardiac homotransplantation.

Autotransplantation . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Department of Surgery and Center for Cardiovascular Research, St. Louis University, and the Henry Baird Favill Laboratory, St. Luke's Presbyterian Hospital and the Pathology Laboratory of Columbus Hospital, Chicago.

Footnotes
Read before the 12th Scientific Meeting of the International Cardiovascular Society, North American Chapter, San Francisco, June 20, 1964.

Supported by a grant from the John A. Hartford Foundation and grants HE-06312, HE-06762, HE-07268, and HE-K3-5616, USPHS and funds given by Mrs. Richard W. Leach.

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