This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Studies During Extracorporeal Circulation

MURRAY W. ANDERSEN, MD; GORAN WILLIAM-OLSSON, MD

AMA Arch Surg. 1965;90(2):290-293.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PREVIOUS reports have demonstrated the frequent occurrence of acute hypocarbia with resultant biochemical changes during extracorporeal circulation² and in association with artificial ventilation during and after operation.^2,6,7 Attention has recently been directed to the relationship between these changes, specifically the marked decrease in serum potassium levels, and abnormalities in cardiac rhythm occurring intra- and postoperatively.⁶ The well known effect of hypokalemia upon the development of digitalis intoxication^5,8 is of primary importance in this respect.

Since the degree of hypocarbia which can be induced by hyperventilation at conventional levels is limited, it was felt that it would be useful to determine whether these biochemical abnormalities would be further increased by induction of more severe hypocarbia and whether electrocardiographic changes secondary to hypokalemia would be induced. A series of experiments was therefore carried out in animals in which extreme degrees of carbon dioxide "washout" were induced by use . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO; STOCKHOLM, SWEDEN

From the Surgical Research Laboratories of the State University of New York at Buffalo and the E. J. Meyer Memorial Hospital.

Footnotes
Submitted for publication Oct 1, 1964.

Reprint requests to 462 Grider St, Buffalo, NY 14215 (Dr. Andersen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?