This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (36)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

STUART D. WILSON, MD; EDWIN H. ELLISON, MD

AMA Arch Surg. 1965;91(1):165-173.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT HAS BEEN only ten years since Zollinger and Ellison first proposed that an ulcerogenic hormone might be elaborated from non-beta, islet cell tumors of the pancreas and result in an ulcer diathesis.²² Gregory was the first to extract a "gastrin-like" substance from these tumors⁹ and Sircus has now demonstrated a gastric secretogogue circulating in the plasma of a patient with the Zollinger-Ellison syndrome.²¹ Many surgeons are still reluctant to do a total gastrectomy in such patients despite the reported influence on survival.^6,12

More than 300 cases are now recorded, and of these, eight are children who have undergone gastric resection for ulcerogenic symptoms. The age of these children at the initial surgical procedure ranged from eight to fifteen years. All of the children experienced bleeding. Seven of the children had evidence of metastasis from islet cell tumors, and one child exhibited hyperplasia of the pancreatic . . . [Full Text PDF of this Article]

Author Affiliations
MILWAUKEE

From the Division of Surgery, Marquette University School of Medicine, its affiliated teaching hospitals, and the Allen-Bradley Medical Science Laboratory, Milwaukee.

Footnotes
Submitted for publication March 16, 1965.

Reprint requests to Marquette University School of Medicine (Dr. Wilson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?