This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MARVIN M. KIRSH, MD; WILLIAM KNAPP, MD; SHERROLL A. NEILL, MD; WILLIAM COON, MD; GEORGE D. ZUIDEMA, MD

AMA Arch Surg. 1965;91(4):640-642.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYPERAMMONEMIA following ingestion of protein has been observed in both animals and humans after portacaval shunt. The rise in levels of ammonia in the systemic circulation has been attributed to direct passage of ammonia-rich portal blood into the vena cava without preliminary transit through the liver.¹ The validity of this hypothesis was tested by comparing the response of a group of animals with portacaval shunt to the response of a group with portacaval transposition after intragastric administration of whole blood.

Experiment

Group 1.

—Eight adult mongrel dogs weighing 10 to 15 kg (22 to 33 1b) were used. The following studies were performed prior to operation: fasting whole blood ammonia, blood urea nitrogen, (BUN), alkaline phosphatase, bilirubin direct and indirect, total serum protein, albumin and globulin, and sodium sulfobromophthalein (Bromsulphalein) retention. An end-to-side portacaval shunt was constructed. Animals were allowed five to seven days to recover from the operation . . . [Full Text PDF of this Article]

Author Affiliations
ANN ARBOR, MICH

From the Department of Surgery, University of Michigan Medical School. Teaching Associates (Drs. Kirsh and Neill), Intern (Dr. Knapp), and Associate Professor (Dr. Coon), Department of Surgery, University of Michigan Medical Center; and Professor and Chairman, Department of Surgery, Johns Hopkins University, John and Mary R. Markle Scholar in Academic Medicine, US Public Health Service Career Development Awardee (Dr. Zuidema).

Footnotes
Submitted for publication March 24, 1965.

Presented at the Surgical Forum of the American College of Surgeons, October 1964.

Reprint requests to 1405 E Ann St, Ann Arbor, Mich 48104 (Dr. Kirsh).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?