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Long-Term Patency of Solid-Wall Vascular Prostheses
P. N. SAWYER, MD;
K. T. WU, MD;
S. A. WESOLOWSKI, MD;
W. H. BRATTAIN, PhD;
P. J. BODDY, PhD
AMA Arch Surg. 1965;91(5):735-742.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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SEVERAL discoveries over the past 15 years have progressively led to the recent suggestion that metals of low work function (high in the electromotive series) would not thrombose on implantation into the aorta or vena cava when used as a prosthetic vessel replacement. A series of experiments based on the above hypothesis has recently been completed. The results appear to confirm the postulate which may now, perhaps, be dignified by the term "theory."
Historically, several of the more important experiments which led to the hypothesis were:
1. Abramson's classical experiments in 1927 to 1942 in which he quantitated the electrophoretic characteristics of blood cells of several mammalia and showed that these all had a negatively charged surface and moved toward the positive pole in an electrophoresis apparatus.1,2
2. The discovery that with onset of thrombosis the normal polarity of an electrode pair, placed across blood vessel wall, reversed. Normally,
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK; MURRAY HILL, NJ
From the Department of Surgery and Surgical Research, the State University of New York, the Downstate Medical Center, Brooklyn, NY, and Bell Telephone Laboratories, Murray Hill, NJ.
Footnotes
Read before the Annual Meeting of the North American Chapter of the International Cardiovascular Society, New York, June 19, 1965.
Reprint requests to 450 Clarkson Ave, Brooklyn, NY 11203 (Dr. Sawyer).
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