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I. MANDELBAUM, MD; J. BERRY, AB; M. SILBERT, AB; W. H. BURNS, MD; C. ROTHE, PhD

AMA Arch Surg. 1965;91(5):771-774.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DIFFERENCES in response to pulsatile and nonpulsatile blood flow might be important during total cardiopulmonary bypass, assisted circulation, and with regard to implantable mechanical hearts.

In previous studies from this laboratory, nonpulsatile flow was found to be associated with increased systemic vascular resistance as compared with pulsatile flow.¹ In the present investigation, renal, hepatic, and hind-limb flows were determined during total body pulsatile and nonpulsatile perfusion in dogs.

Method

1. Ten healthy mongrel dogs, each weighing 12 to 22 kg (26.4 to 48.4 lb) were anesthetized lightly with intravenous 5% thiopental (Pentothal). Adequate ventilation with oxygen was maintained by use of a mechanical respirator connected to an endotracheal tube. The animals were given 2 mg/kg sodium heparin. A polyethylene catheter was inserted into a femoral artery and another was placed in the left innominate vein through the left jugular vein. They were connected to individual strain gauges, and systemic . . . [Full Text PDF of this Article]

Author Affiliations
INDIANAPOLIS

From the departments of surgery and physiology, Indiana University School of Medicine.

Footnotes
Read before the Annual Meeting of the North American Chapter of the International Cardiovascular Society, New York, June 19, 1965.

Reprint requests to Indiana University School of Medicine, Indianapolis, Ind 46207 (Dr. Mandelbaum).

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