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Cardiovascular Response After Cardiac Autotransplant in Primate
V. L. WILLMAN, MD;
THEODORE COOPER, MD, PhD;
GEORGE C. KAISER, MD;
C. ROLLINS HANLON, MD
AMA Arch Surg. 1965;91(5):805-806.
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TRANSPLANTATION RANSPLANTATION of the heart results in complete cardiac denervation which has been shown to cause significant chemical,1 histological,2,3 metabolic,4 and functional5 changes in the dog. In anticipation of cardiac homotransplantation in man, we have studied the effects of cardiac denervation in another primate. This presentation details the studies in nine normal baboons as controls and in six baboons with autotransplanted hearts and three with hearts completely separated from extrinsic neural connections.
Methods
Autotransplantation by the technique described in the dog6 was performed in ten baboons. Six animals surviving longer than one month were available for study along with three animals more than one month after total mediastinal neural ablation.7 Nine animals were taken at random as normal controls from a large baboon colony.
In all 18 animals, cardiac output (CO) was determined by dye dilution technique with indocyanine green (Cardiogreen) injection into a
. . . [Full Text PDF of this Article]
Author Affiliations
ST. LOUIS
From the Department of Surgery, St. Louis University School of Medicine.
Footnotes
Submitted for publication July 10, 1965.
Read before the Annual Meeting of the North American Chapter of the International Cardiovascular Society, New York, June 19, 1965.
Reprint requests to 1325 S Grand Blvd, St. Louis, Mo 63104 (Dr. Willman).
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