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JOHAN VAN WYK, MB, ChB; IVAN TAIT, FRCS; BEN EISEMAN, MD

AMA Arch Surg. 1966;92(1):87-90.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HEPATIC VENOUS outflow obstruction has proved to be an important factor in the pathogenesis of ascites formation. Experimental procedures^1,2 which involve ligation of the hepatic veins in the dog produce a consistent controllable method for the production of ascites. A comprehensive study of the hepatic circulation by corrosion casts in cirrhotic patients³ led to the conclusion that the primary factor in the pathogenesis of ascites formation in these patients was hepatic outflow block.

It was observed during ex-vivo perfusion of the pig liver in this laboratory that clear fluid was produced on the liver surface and that during outflow obstruction this fluid production increased in quantity. This led to the design of this series of experiments to study the quantitative effect of increasing outflow tract pressures on the rate and composition of ascites formation. A further observation during these experiments, namely the improvement in the gross appearance of . . . [Full Text PDF of this Article]

Author Affiliations
LEXINGTON, KY

From the Department of Surgery, University of Kentucky Medical School, Lexington.

Footnotes
Submitted for publication Aug 20, 1965.

Reprint requests to Department of Surgery, University of Kentucky Medical Center, Lexington, Ky 40506 (Dr. Eiseman).

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