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JAMES CERILLI, MD; PAUL LAURIDSEN, MD; JUSTUS SAURBREY, MD; ERIK HUSFELDT; H. H. WANDALL, MD, DM Sc

AMA Arch Surg. 1966;92(2):178-183.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MINIMIZING ischemic damage to a donor kidney to insure prompt function is an important factor in successful renal homotransplantation. The purpose of this experiment was to test if mannitol would be useful for this purpose and to compare its effectiveness and possible mechanism of action with that of saline and urea.

Methods

Twenty-three dogs were anesthetized with pentobarbital (Nembutal) and placed on a respirator with room air. Carotid-artery pressure was continuously recorded. Test solutions were injected into an external jugular catheter. The left kidney was excised and connected to the right iliac vessels. Bilateral catheters were inserted.

Twenty percent mannitol, 20% urea, 6.7% urea, and normal saline were injected over three to four minutes using the following doses: 20% mannitol at 500 mg/kg (2.5 cc/kg); 20% urea at 500 mg/kg (2.5 cc/kg); 6.7% urea at 167 mg/kg (2.5 cc/kg); normal saline at 2.5 cc/kg.

Solutions of 6.7% and 20% urea . . . [Full Text PDF of this Article]

Author Affiliations
DENVER; COPENHAGEN

From the Institute of Experimental Research and Surgery, University of Copenhagen.

Footnotes
Submitted for publication Oct 11, 1965.

Reprint requests to 4200 E Ninth Ave, Denver, Colo 80220 (Dr. Cerilli).

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