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S. FRANK REDO, MD; SHARON DIME, BS

AMA Arch Surg. 1966;92(2):269-272.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ALTHOUGH successful cardiac homotransplantation depends largely on solving immunological problems causing the rejection phenomenon, methods of acquiring and storing hearts must be developed to make the procedure more widely applicable. A previous publication¹ reported investigations aimed at determining the length of time after death that guinea pig hearts could be removed and still function effectively. Hearts removed more than 15 minutes after death failed to reach contractile amplitudes or forces equal to those of control hearts removed from live, anesthetized animals. While it appears that hearts can be removed after death and still function effectively, in the guinea pig at least, this interval between death and removal of the heart seems relatively short. The present study, using isolated, perfused, guinea pig hearts, was aimed at evaluating several storage techniques to determine how long guinea pig hearts could be stored and still function effectively.

Materials and Methods

Guinea pigs weighing . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Surgery, Cornell University Medical College, New York.

Footnotes
Submitted for publication Aug 16, 1965.

Reprint requests to 525 E 68th St, New York, NY 10021 (Dr. Redo).

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