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I. Incubation Procedures

AVERIL O. MANSFIELD, MB, ChB; JOHN M. HOWARD, MD

AMA Arch Surg. 1966;92(3):407-413.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THESE background experiments have been undertaken in order to determine whether it is possible to mobilize chemically any of the lipids present in atherosclerotic plaques with the ultimate objective of applying the principle of regional isolation perfusion, as developed by Creech for regional cancer therapy, to the patient with diffuse atherosclerosis of a limb or organ. With such an objective, this first step was undertaken to determine the amount of lipid which could be removed from the atherosclerotic vessel under conditions of in vitro incubation of the vessel with various lipid "solvents."

Background

The term atherosclerosis describes a specific disease process, one among the arterioscleroses; it is characterized by focal thickenings of the intima in which stainable lipids can readily be demonstrated in and between the cellular elements.¹

The earliest lesion is the fatty streak. By stripping the intima of an early lesion it is possible to remove the . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

From the Department of Surgery, Hahnemann Medical College, Philadelphia.

Footnotes
Submitted for publication Nov 23, 1965.

Reprint requests to 230 N Broad St, Philadelphia, Pa 19102 (Dr. Howard).

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