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In Vitro Mobilization of Atherosclerotic Plaque LipidsII. Perfusion
AVERIL O. MANSFIELD, MB, ChB;
JOHN M. HOWARD, MD
AMA Arch Surg. 1966;92(3):414-417.
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THIS investigation has been undertaken in order to determine whether it is possible to mobilize the lipids present in an atherosclerotic plaque and thereby to remove some of them using a perfusion technique. A previous experiment has demonstrated that certain substances are capable of mobilizing fats when, in vitro, they are incubated with the arteries. The current study has been an extension of the study of the mobilization of the lipids in vitro by perfusion of the arteries. Ultimately, the aim of the study would include the application of the isolation perfusion technique developed by Creech and associates1 as in the treatment of cancer
The chemistry of the atherosclerotic vessel, having been reviewed in the previous paper, is not included here. The results obtained by Buck and Rossiter2 (Table 1, p 407, this issue) form the basis of comparison with the present results.
The perfusants selected were based
. . . [Full Text PDF of this Article]
Author Affiliations
PHILADELPHIA
From the Department of Surgery, Hahnemann Medical College, Philadelphia.
Footnotes
Submitted for publication Nov 23, 1965.
Reprint requests to 230 N Broad St, Philadelphia, Pa 19102 (Dr. Howard).
Part I published on p 407 in this issue.
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