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Relation of Blood Levels of Serum Glutamic Oxaloacetic Transaminase, Lactic Dehydrogenase, and Heat Stable Lactic Dehydrogenase to Size of Experimental Myocardial Infarct

DUNCAN A. KILLEN, MD; ELLIS A. TINSLEY, MD

AMA Arch Surg. 1966;92(3):418-422.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE IS no known accurate technique of clinical quantitation of myocardial infarct size.¹ During the past decade practical methods of measuring the serum values of certain enzymes, present in abnormally elevated levels in the presence of myocardial necrosis, have been applied widely as diagnostic tests for the presence of myocardial infarction. The reliability of the correlation of infarct size with the magnitude of serum enzyme elevation has not been precisely established. A method based on myocardial distribution of intravenously administered radioactive rubidium (⁸⁶Rb) has been used recently to quantitate the size of experimentally produced myocardial infarcts. In the present study the elevation of the serum glutamic oxaloacetic transaminase (SGOT), lactic dehydrogenase (LDH), and heat stable lactic dehydrogenase (LDH) following coronary artery ligation was assessed in relation to myocardial infarct size as determined by macroscopic examination (dissection) at autopsy and by the radioactive rubidium distribution technique

Methods

Myocardial infarcts . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN

From the Surgical Research Laboratory, Veterans Administration Hospital, and the Department of Surgery, Vanderbilt University School of Medicine, Nashville.

Footnotes
Submitted for publication Aug 16, 1965.

Reprint requests to 1310 Twenty-fourth Ave, South, Nashville, Tenn 37203 (Dr. Killen).

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