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JAMES B. GROGAN, PhD

AMA Arch Surg. 1966;92(5):740-742.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

HYPERBARIC oxygen has been used successfully as a treatment regimen in severe infections caused by certain anaerobic bacteria, especially Clostridium welchii gas gangrene.¹ The rationale behind this type of treatment is sound since anaerobic bacteria are highly sensitive to oxygen, but strict limitations are necessary because of detrimental effects of high pressure oxygen on the patient.

In vitro experiments have shown that hyperbaric oxygen is also inhibitory to aerobic microorganisms.^2,3 Little is known, however, about the effects of hyperbaric oxygen on the growth and pathogenesis of aerobic bacteria in vivo. A preliminary study in this laboratory indicated that hyperbaric oxygenation enhanced the incidence of deaths among staphylococcal infected mice.⁴ This report is an extension of that work and includes studies of Pseudomonas-infected mice treated with hyperbaric oxygen.

Materials and Methods

For these studies, a strain of Staphylococcus aureus isolated from a wound infection and a strain . . . [Full Text PDF of this Article]

Author Affiliations
JACKSON, MISS

From the Department of Surgery, University of Mississippi Medical Center, Jackson.

Footnotes
Submitted for publication Jan 21, 1965.

Reprint requests to 2500 N State St, Jackson, Miss 39216.

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