This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Experimental Studies

MELVIN A. BLOCK, MD; E. J. TWOREK, MD; J. MARTIN MILLER, MD

AMA Arch Surg. 1966;92(5):778-784.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EXPERIMENTAL studies in the past have suggested that the brain is a "privileged site" for homografts. The brain lacks a lymph node drainage system. Therefore, parathyroid homografts were experimentally implanted into the brains of dogs and rabbits to assess the significance of the brain as a "privileged site" and also the significance of regional lymph nodes in the homograft reaction. Microscopic studies of the implants and serum calcium determinations were criteria used in evaluating the status of the implants.

Permanently viable homografts of parathyroid tissue into brain were not achieved in these experiments. Parathyroid autografts did survive. Homografts were uniformly rejected within several weeks. Fat cells seemed to survive for longer periods in some animals and served to make the implantation site.

These experiments indicate that the brain is not sufficiently "privileged" to be of value as a homograft site in these species. Although lymph nodes and certainly lymphocytes appear . . . [Full Text PDF of this Article]

Author Affiliations
DETROIT

From the divisions of general surgery and endocrinology, Henry Ford Hospital, Detroit.

Footnotes
Submitted for publication Jan 10, 1966.

Reprint requests to 2799 W Grand Blvd, Detroit, Mich 48202 (Dr. Block).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?