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M. KAKVAN, MD; E. SARKOZY, MSc; ANTHONY R. C. DOBELL, MD

AMA Arch Surg. 1966;92(6):898-900.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PREVIOUS experiments in this laboratory have demonstrated our ability to support dogs with extreme airway obstruction by means of an extracorporeal pump-oxygenator.¹ A prepulmonary bypass² was established in which venous blood was drained by gravity and then propelled through a membrane-oxygenator and returned to another systemic vein. Clinical application of this technique would be in infants with respiratory distress syndrome, most of whom are premature. The present experiments were designed to provide experience in dealing with subjects weighing about 2 kg (4.4 lb) and to determine whether complete airway occlusion for one hour could be tolerated by these small subjects while gas exchange was accomplished outside the body. The choice of a membraneoxygenator was necessitated by the fact that prolonged extracorporeal circulation would be required in the clinical application. Oxygenators with a blood gas interface are unsatisfactory³ for prolonged perfusions probably due to protein denaturation at that . . . [Full Text PDF of this Article]

Author Affiliations
MONTREAL

From the Department of Cardiovascular Surgery, Montreal Children's Hospital, and the Department of Experimental Surgery, McGill University, Montreal.

Footnotes
Submitted for publication Feb 5, 1966.

Reprint requests to Room 1137, Montreal Children's Hospital, Montreal 25, Quebec, Canada (Dr. Dobell).

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