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Correlation With Laboratory Tests of Hemostatic Function

ALAN S. TRIMBLE, MD, FRCS (C); ROSLYN HERST, MD; MARION GRADY, ART; JOHN H. CROOKSTON, MD, PhD

AMA Arch Surg. 1966;93(2):323-326.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SEVERAL studies of the prevention and treatment of excessive bleeding in extracorporeal circulation have been published.^1-17 While inadequate surgical hemostasis^11,12,15 and incomplete heparin neutralization^7,8,15-17 are the most common causes of hemorrhage, changes in the platelets and plasma coagulation factors do occur, but they only occasionally contribute to blood loss.^{2-8,10-14,16,17}

For the past five years, all candidates for open heart surgery at the Toronto General Hospital have routinely had preoperative studies of hemostatic function. During the past year similar tests have also been performed at the completion of perfusion. This review was undertaken in order to determine the cause of excessive blood loss and to assess the ability of the preoperative hemostatic tests to predict operative hemorrhage. While major bleeding is now an infrequent complication after cardiopulmonary bypass at this hospital, a recent survey¹⁸ suggests that bleeding is still a major problem with some teams of . . . [Full Text PDF of this Article]

Author Affiliations
TORONTO

From the Cardiovascular Unit, the Division of Cardiovascular Surgery and the Department of Laboratories, Toronto General Hospital.

Footnotes
Submitted for publication March 1, 1966.

Reprint requests to Cardiovascular Unit, Toronto General Hospital, Toronto, Ontario, Canada (Dr. Trimble).

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