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Occurrence in Patients Undergoing Open Heart Surgery

BRACK G. HATTLER, JR., MD; W. GLENN YOUNG, JR., MD; D. B. AMOS, MD; PETER HUTCHIN, MD; M. MacQUEEN

AMA Arch Surg. 1966;93(5):741-746.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

LEUKOCYTES are known to carry transplantation antigens both in animals¹ and in man.^2,3 Should transfusions of blood from one individual to another, therefore, be considered as a homograft and to what extent do blood transfusions sensitize for a subsequent graft? It is known that whereas in stored blood the leukocytes are not well preserved,^4-6 they survive nicely in freshly drawn heparinized blood.^7,8 It is not surprising, therefore, that leukocyte antibodies have been demonstrated following massive transfusions of fresh blood containing living leukocytes. Using the approach of Walford and his colleagues,^8-10 we have sought to further investigate this problem by examining the sera of patients undergoing open heart surgery. During cardiopulmonary bypass, the patient receives a large quantity of fresh whole blood. Such a transfusion given to an immunologically competent individual should constitute, therefore, a homograft stimulus of some magnitude. With this in mind, we have . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, NC

From the Division of Thoracic Surgery, Department of Surgery, and the Division of Immunology, Department of Microbiology, Duke University Medical Center, Durham.

Footnotes
Read before the 14th Scientific Meeting of the North American Chapter of the International Cardiovascular Society, Chicago, June 25, 1966.

Reprint requests to Department of Surgery, Duke University Medical Center, Durham, NC 27706 (Dr. Hattler).

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