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FABIO GIRON, MD; WILLIAM C. BIRTWELL, BS; HARRY S. SOROFF, MD; RALPH A. DETERLING, JR., MD

AMA Arch Surg. 1966;93(5):802-810.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE RENEWED interest in the physiologic effects of pulsatile and nonpulsatile flow has been, in large measure, stimulated by the desire to support the circulation for prolonged periods with extracorporeal devices. The excellent studies of Mandelbaum and associates,^1,2 Wesolowski,³ Ogata and associates,⁴ Nakayama et al,⁵ and Dalton et al⁶ have all used extracorporeal devices to provide either pulsatile or nonpulsatile flow. While these studies have been illuminating and have generally pointed to a significant increase in pressure and resistance in response to a nonpulsatile flow, the use of extracorporeal devices as the source of the flow has made the application of these findings to the intact organism open to serious question.

This group has adopted a different approach. We have introduced an experimental model for studying the chronic effects of depulsation in which the aortic flow is exteriorized through a subcutaneous graft anastomosed in-series to . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Surgery, Tufts University School of Medicine and New England Medical Center hospitals, Boston.

Footnotes
Read before the 14th Scientific Meeting of the North American Chapter of the International Cardiovascular Society, Chicago, June 25, 1966.

Reprint requests to 171 Harrison Ave, Boston 02111 (Dr. Deterling).

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