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H. GIBBS ANDREWS, MD; HARRIS B SHUMACKER, JR., MD

AMA Arch Surg. 1966;93(5):824-827.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CERTAIN cardiac procedures might be more uniformly successful and free of complications if it were possible to maintain for a period of time a prolonged coagulation time of the blood within the heart and, at the same time, a normal clotting mechanism in the systemic circuit. The successful utilization of regional heparinization in conjunction with hemodialysis^1,2 in extracorporeal liver perfusion studies³ provided a new element of hope and prompted the present study.

Experimental Procedure

Healthy mongrel dogs, ranging in weight from 7.4 to 26.4 kg, were used. They were anesthetized by the intravenous administration of thiopental sodium (Pentothal). Following tracheal intubation, controlled respirations were maintained with a mechanical ventilator. Two groups of animals were studied.

In the first group of 28 dogs, sodium heparin was administered through a No. 18 polyethylene catheter inserted into the left atrium through its appendage. Blood samples were drawn from 12-gauge Teflon catheters . . . [Full Text PDF of this Article]

Author Affiliations
INDIANAPOLIS

From the Department of Surgery and the Heart Research Center, Indiana University School of Medicine, Indianapolis.

Footnotes
Submitted for publication Oct 18, 1965.

Reprint requests to 1100 W Michigan St, Indianapolis 46207 (Dr. Shumacker).

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