This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (2)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

TIMOTHY MILLER, MD; JOHN H. FOSTER, MD

AMA Arch Surg. 1966;93(6):962-966.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

INTEREST in the hypertensive effect of renal artery stenosis dates back to the work of Katzenstien and of Janway in the early 1900's. However, it was not until some 25 years later that the experiments of Goldblatt established the effect of the ischemic kidney on blood pressure. Additional work by others established a relationship between the ischemic kidney, renin, and angiotensin. Recently angiotensin and renal ischemia have been implicated not only as etiologic factors in hypertension, but in other profound metabolic effects. Several authors have shown that angiotensin is related to the secretion of aldosterone presumably in the normal as well as in pathologic states.^1-3 In addition definite effects on renal tubular function have been suggested.^3,4 In the past few years an association has been noted between renovascular hypertension (particularly malignant hypertension), hypokalemia, and hyperaldosteronism in patients without primary adrenal pathology.^5-11 In approximately half of these cases, . . . [Full Text PDF of this Article]

Author Affiliations
NASHVILLE, TENN

From the Department of Surgery, Vanderbilt University School of Medicine and Vanderbilt University Hospital, Nashville.

Footnotes
Submitted for publication June 20, 1966.

Reprint requests to Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tenn 37203 (Dr. Foster).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?