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Hemodynamic and Survival Effects of Methylprednisolone

LERNER B. HINSHAW, PhD; LURA A. SOLOMON, BS; PATRICK C. FREENY, BA; DALE A. REINS, MS

AMA Arch Surg. 1967;94(1):61-66.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE USE of corticosteroids in shock is a subject of much recent interest.^1-15 Although varied claims have been made for the effectiveness of these agents in shock, there appear to have been no adequately controlled studies in clinical shock.¹⁶ There is evidence that corticosteroids are protective to dogs^4,7,8,11 and other animals^1-3 in endotoxin shock. Different theories about the protective actions of steroids have been advanced based on clinical and animal studies.^{4,11,13,17-20}

The present study was designed to investigate the survival and early hemodynamic effects of the synthetic corticosteroid, methylprednisolone sodium succinate (Solu-Medrol), on pulmonary and peripheral vascular beds when administered to dogs following an 80% lethal dose of Escherichia coli endotoxin.

Methods

Experiments were carried out on 82 adult mongrel dogs of both sexes, anesthetized with sodium pentobarbital, 30 mg/kg body weight, administered intravenously. A series of survival experiments was carried out on 30 dogs . . . [Full Text PDF of this Article]

Author Affiliations
OKLAHOMA CITY

From the Veterans Administration Hospital, and the departments of surgery and physiology, University of Oklahoma Medical Center, Oklahoma City.

Footnotes
Submitted for publication July 11, 1966.

Reprint requests to Veterans Administration Hospital, 921 NE 13th St, Oklahoma City 73104 (Dr. Hinshaw).

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