This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (19)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

MASUHIKO TAKAORI, MD, PhD; PETER SAFAR, MD

AMA Arch Surg. 1967;94(1):67-73.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

LIMITATIONS in the use of blood substitutes in severe hemorrhage in dogs have been studied in our laboratory using a new experimental model.^1-3 Severe acute anemia (to 10% hematocrit reading) was produced by serial blood withdrawals (10 ml/kg each every ten minutes) and immediate infusion of equal volumes of colloid solution (dextran 40, dextran 75, or hydroxyethyl starch). Long-term survival was obtained in 80% of 43 animals studied. Early compensation was by increased cardiac output and increased coefficient of oxygen extraction.* Late compensation was by increased coefficient of oxygen extraction and erythropoiesis.

Limitations of the treatment of hemorrhage with salt solutions are still not clear, partially because of varying results obtained with different experimental methods. Ebert and associates⁴ showed that following hemorrhage, infusion of saline solution alone could not maintain plasma volume unless circulating protein was restored. In our pilot experiments during which blood was replaced with equal . . . [Full Text PDF of this Article]

Author Affiliations
PITTSBURGH

From the Department of Anesthesiology, University of Pittsburgh School of Medicine and Presbyterian-University Hospital, Pittsburgh. Dr. Takaori was a research fellow; his present address is Department of Anesthesiology, University of Osaka School of Medicine, Osaka, Japan.

Footnotes
Submitted for publication Aug 5, 1966.

Reprint requests to Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh 15213 (Dr. Safar).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?