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EDGARDO REHDER, MD; IRVING F. ENQUIST, MD

AMA Arch Surg. 1967;94(1):74-78.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CORTISONE'S interference with wound healing has been well documented in experimental studies,^1-3 but surgeons are not convinced that patients receiving cortisone suffer unduly from wound complications. That species differences may play a role is strongly suggested in the nice study of Shewell and Long⁴ who studied the effect of cortisone in six different animal species and found that there were two distinct groups: one group was sensitive to cortisone and one was not. Studying changes in body and organ weights, -globulin formation, and antibody production, they showed cortisone sensitivity in rabbits, ferrets, rats, and mice, but a refractoriness to cortisone in guinea pigs and rhesus monkeys. The species differences were clear cut and complete.

Because surgeons have often referred to a lack of cortisone effect in patients and because guinea pigs and monkeys do not respond to cortisone like the standard laboratory animals, a test of the cortisone . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN, NY

From the departments of surgery, Methodist Hospital of Brooklyn and the State University of New York, Downstate Medical Center, Brooklyn.

Footnotes
Submitted for publication Sept 6, 1966.

Reprint requests to Methodist Hospital of Brooklyn, 506 Sixth St, Brooklyn, NY 11215 (Dr. Enquist).

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