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DAVID A. WEILBAECHER, MD; GEORGE H. BORNSIDE, PhD; ISIDORE COHN, JR., MD

AMA Arch Surg. 1967;94(1):8-10.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

BACTERIA exert an inhibitory effect on the growth of tumors of the colon. Vink¹ first demonstrated this experimentally in 1954. He reported that control of the bacterial flora of the colon by intestinal antisepsis increased the incidence of tumor growth at an anastomotic site in the colon. Cohn and Atik² found an increase in growth of the Brown-Pearce carcinoma at the anastomotic site in rabbits when the intestinal flora was reduced and trauma increased. Christensen and Kjems^3,4 demonstrated that rabbits with Brown-Pearce tumor growing in the testicle had a diminished incidence of metastases following massive streptococcal infection or therapy with lysates of streptococci. Miller and Ketcham⁵ showed a decrease in the implantation and growth of tumor cells in experimental, infected, operative wounds in mice and reported that an intimate contact between bacteria and tumor cells was necessary for inhibition of tumor growth, since infection at a . . . [Full Text PDF of this Article]

Author Affiliations
NEW ORLEANS

From the Department of Surgery, Louisiana State University School of Medicine, New Orleans.

Footnotes
Submitted for publication July 2, 1966.

Reprint requests to Department of Surgery, Louisiana State University School of Medicine, 1542 Tulane Ave, New Orleans 70112 (Dr. Cohn).

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