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Bone Induction in Excavation Chambers in Matrix of Decalcified Dentin
Gisle Bang, DDS, MD;
Marshall R. Urist, MD
AMA Arch Surg. 1967;94(6):781-789.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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EXPERIMENTS by Charles B. Huggins and his associates,1 and many others during the past thirty years,2-11 demonstrate that whole toothbuds and parts of toothbuds possess the capacity to grow and develop in areas of the body other than the jawbone, even in the form of explants in tissue culture. The toothbud not only continues its characteristic development, but also exhibits the capacity to induce undifferentiated connective tissues to form bone. To explain these observations, Hoffman12 postulates that the enamel organ and its derivative, Hertwig's epithelial root sheath, stimulates connective tissue cells to differentiate into bone cells, while Zussman13 contends that odontoblasts which had previously participated in dentin formation can produce bone even when not in contact with oral tissues. Except that the new bone originates from proliferating living cells in both the transplanted tooth and in the host bed, present knowledge of the local physiology of
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Department of Surgery, Division of Orthopedics, Bone Research Laboratory, Los Angeles. Dr. Bang was a Postdoctoral Research Fellow, 1965-1966, on sabbatical leave from the University of Bergen, Department of Pathology, Gades Institutt, Bergen, Norway.
Footnotes
Submitted for publication Nov 21, 1966.
Reprint requests to Department of Surgery, University of California School of Medicine, Center for the Health Sciences, Los Angeles 90024 (Dr. Urist).
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