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Herbert Schapiro, PhD; Louis G. Britt, MD

AMA Arch Surg. 1967;94(6):841-844.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EARLY IN the work with histamine, it was reported by Popielski¹ and by Keeton and associates² that this drug produced a gastric secretory response after section of the vagus nerves to the otherwise intact stomach. Ivy and Javois³ found that histamine would stimulate gastric secretion in a denervated gastric pouch and Klein⁴ reported that a similar response could be obtained from a transplanted gastric pouch that had been deprived of its muscular layers and myenteric plexus. In 1948, Oberhelman and Dragstedt⁵ noted that the gastric secretory response to a standard dose of histamine in dogs with a totally isolated stomach pouch was markedly reduced (44% to 77%) following bilateral vagotomy; and in 1961, Gelb and associates⁶ reported that the maximal histamine response in patients studied before and after vagotomy was reduced 59% to 93%. In 1964, Anderson and Olbe⁷ reported that vagal denervation . . . [Full Text PDF of this Article]

Author Affiliations
Memphis, Tenn

From the departments of anatomy and surgery, School of Basic Medical Sciences and School of Medicine, University of Tennessee Medical Units, Memphis.

Footnotes
Submitted for publication Dec 20, 1966.

Reprint requests to Department of Anatomy, University of Tennessee Medical Units, 875 Monroe St, Memphis, Tenn 38103 (Dr. Schapiro).

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