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Higher Homologous Cyanoacrylate Tissue Adhesives in Surgery of Internal Organs
Lt Col Teruo Matsumoto, MC;
Col Robert M. Hardaway, III, MC;
Maj Charles A. Heisterkamp, III, MC;
K. C. Pani, MD;
Fred Leonard, PhD
AMA Arch Surg. 1967;94(6):861-864.
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THE n-ALKYL- -cyanoacrylate monomers have the ability to adhere to moist living tissues. Methyl--cyanoacrylate monomer, in particular, has been used since 1960 by many investigators as a tissue adhesive for various surgical procedures, although the monomer is not widely used in clinical surgery. This is because of two factors: histotoxicity and relative failure of adhesive versus suture techniques. It is our belief that the success of surgical application of the cyanoacrylate tissue adhesive is dependent on the new surgical techniques suitable for the use of monomers in addition to development of a better monomer(s). New techniques have been developed at this Institute using the higher homologous monomers.
This paper evaluates the various higher homologous monomers used for the surgery of internal organs. (Table 1). A useful tissue adhesive must possess several properties. These are (1) shelf stability, (2) polymerization in the presence of moisture to a thin polymer film, (3) adequate
. . . [Full Text PDF of this Article]
Author Affiliations
USA; USA; USA; Washington, DC
From the Division of Surgery, Walter Reed Army Institute of Research, Washington, DC. Drs. Pani and Leonard are with the US Army Medical Biomechanical Research Laboratory, Walter Reed Army Medical Center, Washington, DC.
Footnotes
Submitted for publication Dec 7, 1966.
Reprint requests to Division of Surgery, Walter Reed Army Institute of Research, Washington, DC 20012 (Dr. Matsumoto).
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